Intramuscular Post-exposure prophylaxis of tetanus: For children single dose of 250 IU should be given. The dose may be increased to 500 IU in case of: 1. Infected wounds where surgically appropriate treatment cannot be achieved within 24 hours. 2. Deep or contaminated wounds with tissue damage and reduced oxygen supply, as well as foreign body injury (e.g., bites, stings or shots), 3. Burns, congelations, 4. Tissue necrosis, 5. Septicaemic abortion, 6. Adults weighing more than the average. In case of extensive burns, it is advisable to administer a second injection of 250 IU human tetanus immunoglobulin after the exsudative phase of the burn has subsided (about 36 hours after onset of the burn). At the same time, 0.5ml of tetanus vaccine in a different extremity with a separate syringe and complete immunization schedule is required to be administered. Therapy of clinically manifest tetanus: For adults and children single doses of 3,000 to 6,000 IU (in combination with other appropriate clinical procedures).