Oxetol 150 Tablet - (150mg)
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৳80.00
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Introduction
Oxetol 150 is a prescription medicine used to treat and prevent epilepsy (seizures). However, it cannot cure epilepsy and will only work to prevent seizures for as long as you continue to take the medicine. Oxetol 150 may be used alone or in combination with other medicines. The dose and how often you need to take it will be decided by your doctor so that you get the right amount to control your symptoms. It may be increased gradually. You can take this medicine with or without food but take it at the same time each day to get the most benefit. It usually takes a couple of weeks to work. It is important to take this medicine regularly and for as long as you are advised, even if you feel well. Missing doses may trigger seizures and, if you stop, your condition may get worse. It should never be stopped suddenly. The most common side effects of this medicine include nausea, vomiting, feeling dizzy, tired or drowsy, and unsteadiness. Most of these are not serious. Keep taking the medicine but talk to your doctor if these side effects bother you or do not go away. However, if you notice a skin rash or redness, tell your doctor straight away. It could develop into a life-threatening skin condition called Stevens-Johnson syndrome. Long-term treatment with this medicine can cause osteoporosis (reduced bone mass) and increase your risk of breaking a bone. Anticonvulsants like this medicine may cause suicidal thoughts and behaviors. If your mood becomes depressed, tell your doctor. This medicine may not be suitable for everybody. Before using it, tell your doctor if you have ever had heart problems, kidney or liver disease, difficulty urinating, depression or suicidal thoughts. Many other medicines can interfere with it and some should not be taken together so tell your doctor all the medicines you are taking to make sure it is safe. If you are pregnant, do not start or stop taking this medicine without asking your doctor. Drinking alcohol should be avoided as it can increase some of the side effects and can also increase your risk of seizures. You may need frequent blood tests to help your doctor make sure you are taking the right dose both before you start and while you are using it.
Uses of Oxetol 150
- Epilepsy/Seizures
Side effects of Oxetol 150
Common
- Headache
- Nausea
- Vomiting
- Double vision
- Fatigue
- Dizziness
- Impaired coordination
- Nystagmus (involuntary eye movement)
- Tremor
- Abnormal vision
- Altered walking
- Sleepiness
How to use Oxetol 150
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Oxetol 150 may be taken with or without food, but it is better to take it at a fixed time.
How Oxetol 150 works
Oxetol 150 is an antiepileptic medication. It controls seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.
What if you forget to take Oxetol 150?
If you miss a dose of Oxetol 150, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
- Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
- Some healthy tips to prevent seizures:
- It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
- It may increase the risk of low sodium levels in the blood. Inform your doctor if you develop difficulty concentrating, memory problems, confusion, weakness, and unsteadiness.
- Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
- Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.
Brief Description
Indication
Partial seizures, Generalised tonic-clonic seizures
Administration
May be taken with or without food.
Adult Dose
Oral Partial seizures Adult: Adjunctive treatment 300 mg PO q12hr initially; may increase at weekly intervals by 600 mg/day up to 1200 mg/day Monotherapy (if converting from other AED) Initial: 300 mg PO q12hr; increase by 600 mg/day qWeek up to 2400 mg/day Reduce and withdraw concomitant antiepileptic drugs (AEDs) over 3-6 weeks while reaching maximum oxcarbazepine dose in 2-4 weeks Monotherapy (if AED naive) Initial: 300 mg PO q12hr; increase by 300 mg/day q3Day to 1200 mg/day divided q12hr Diabetic Neuropathy 150-300 mg/day PO initially; may increase to 900-1200 mg/day (general recommendation) Neuralgia/Neuropathy 300 mg PO q8-12hr initially; may adjust dose to 400-2000 mg divided q8-12hr (maximum tolerated or effective dose) Hepatic impairment Mild to moderate: No dose adjustment required Severe: Unknown if dosage adjustment necessary
Child Dose
Partial Seizures (Adjunctive Treatment) (age 2-4 years) Initial: 8-10 mg/kg/day PO divided q12hr; not to exceed 600 mg/day <20 kg: May start with16-20 mg/kg/day; may titrate to higher dose over 2-4 weeks; not to exceed 60 mg/kg/day (age 4-16 years) Initial: 8-10 mg/kg/day PO divided q12hr; not to exceed 600 mg/day Target maintenance dose: May titrate to higher dose over 2 weeks to reach the following dosage ranges 20-29 kg: 450 mg PO q12hr 29.1-39 kg: 600 mg PO q12hr >39 kg: 900 mg PO q12hr Partial Seizures (Monotherapy) (age 4-16 years) AED: Initial, 8-10 mg/kg/day PO divided q12hr; may increase qWeek by maximum increment of 10 mg/kg/day AED-naive: Initial 8-10 mg/kg/day PO divided q12hr; may increase q3Days by 5 mg/kg/day Target maintenance: Weight-based dosing may be as high as 2100 mg/day for >60 kg 20-24.99 kg: 600-900 mg/day 25-34.99 kg: 900-1200 mg/day 35-44.99 kg: 900-1500 mg/day 45-49.99 kg: 1200-1500 mg/day 50-59.99 kg: 1200-1800 mg/day 60-69.99 kg: 1200-2100 mg/day 70 kg: 1500-2100 mg/day
Renal Dose
Renal impairment CrCl <30 mL/min: Decrease initial dose by 50%, titrate up slowly
Contraindication
Hypersensitivity. Lactation.
Mode of Action
Oxcarbazepine blocks voltage-sensitive sodium channels, which inhibits repetitive firing, stabilises hyperexcited neuronal membranes and decreases release of synaptic impulses. These effects may prevent the spread of epileptic seizures.
Precaution
Patient carrying the HLA-B*1502 allele. Avoid abrupt withdrawal. Severe renal and hepatic impairment. Pregnancy. Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Monitor seizure frequency, serum Na, symptoms of CNS depression, hypersensitivity reactions, serum levels of concomitant antiepileptic drugs during titration; periodic thyroid function test and CBC. Lactation: Oxcarbazepine and its active metabolite (MHD) are excreted in human milk; milk-to-plasma concentration ratio of 0.5 was found for both Because of the potential for serious adverse reactions in nursing infants, a decision should be made as to whether a mother should discontinue nursing or whether she should discontinue use of the drug, taking into account the drug's importance to the mother
Side Effect
>10% Dizziness (30-50%),Diplopia (30-50%),Headache (26-30%),Nausea/vomiting (26-30%),Nystagmus (26-30%),Somnolence (26-30%),Ataxia (10-30%),Abnormal gait (16-20%),Tremor (16-20%),Abdominal pain (11-15%),Fatigue (11-15%),Vertigo (11-15%),Vision abnormalities (11-15%) 1-10% Dyspepsia (5-6%),Rash (4%),Insomnia (2-4%),Abnormal thinking (<4%),Hyponatremia (1-3%),Muscle weakness (1-2%),Hypotension (<2%),Speech disorder (1%),Asthenia
Interaction
Reduced serum levels with carbamazepine, phenobarbitone, phenytoin, valproic acid. May reduce levels/effects of CYP3A4 substrates (e.g. benzodiazepines, calcium channel blockers, clarithromycin, ciclosporin, erythromycin, oestrogens, mirtazapine, nateglinide, nefazodone, nevirapine, protease inhibitors, tacrolimus, venlafaxine). May reduce efficacy of oral contraceptives. May reduce levels/effects of maraviroc. May increase levels of phenobarbitone, phenytoin.
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