Intramuscular Active immunisation against hepatitis B Neonates and children up to 19 years of age: The recommended dose of Hepatitis B vaccine (rDNA) is 10 mcg of antigen protein in 0.5 ml. Adults 19 years of age and older: The recommended dose of Hepatitis B vaccine (rDNA) is 20 mcg of antigen in 1 ml. The usual immunization regimen consists of 3 doses of vaccine for adult and children. 0,1 and 6 months First dose: at selected date, Second dose: 1 month later after first dose, Third dose: 6 months after first dose. Or Accelerated schedule for all ages- 0,1,2 and 12 months First dose: at elected date, Second dose: 1 month later after first dose, Third dose: 2 months after first dose, Fourth dose: 12 months after first dose. Neonate born to hepatitis B surface antigen-positive mother 4 doses of 10 micrograms: First dose: at birth with hepatitis B immunoglobulin injection (separate site), Second dose: 1 month after the first dose, Third dose: 2 months after the first dose, Fourth dose: 12 months after the first dose. Renal insufficiency (including haemodialysis patients) Adult and child over 16 years 4 doses of 40 micrograms- First dose: at appropriate date, Second dose: 1 month after the first dose, Third dose: 2 months after the first dose, Fourth dose: 6 months after the first dose. Booster doses should be assessed by annual antibody to hepatitis B surface antigen (anti-HBs) testing. A booster dose should be administered when anti-HBs levels decline to <10 mIU/ml.