Firmagon Injection - (80mg)

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৳21,884.00 ৳23,036.00 /pc -5%
Club Point: 999999.99
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(2580 available)
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Ashik Medical
Bolaspur Mymensingh
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Introduction
Firmagon is used in the treatment of advanced prostate cancer. It works by lowering the amount of testosterone produced in the body and restricts the growth of a cancer cell. Firmagon is given as an injection under the skin only under the supervision of a doctor. Do not try to self inject the medicine as it might enhance the chances of an accident or get injected into the veins. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. The most common side effects of this medicine include Injection site reactions (pain, swelling, redness), weight gain, hot flashes, increased liver enzyme, and low sexual desire. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. If you notice dizziness or trouble sleeping, then better to avoid driving or machinery work. Before taking this medicine, tell your doctor if you have ever had heart disease, or diabetes or liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Tell your doctor if you are pregnant or breastfeeding. Your doctor may check for prostate specific antigen (PSA) level in your blood, to know treatment is working or not.
Uses of Firmagon
  • Prostate cancer
Side effects of Firmagon
Common
  • Injection site reactions (pain, swelling, redness)
  • Weight gain
  • Hot flashes
  • Increased liver enzymes
  • Low sexual desire
  • Erectile dysfunction
How to use Firmagon
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Firmagon works
Firmagon lowers the amount of testosterone (a male hormone) produced by the body. This may slow or stop the spread and growth of prostate cancer cells that need testosterone to grow.
What if you forget to take Firmagon?
If you miss a dose of Firmagon, please consult your doctor.
Quick Tips
  • Firmagon helps in the treatment of advanced hormone-dependent prostate cancer.
  • It is give by injection under the skin (subcutaneously), usually in the stomach area.
  • It may cause dizziness and blurred vision. Do not drive or do anything that requires mental focus until you know how it affects you.
  • It may cause hot flashes. Try wearing loose clothing and avoid alcohol, caffeine, and spicy foods.
  • Inform your doctor if you are diabetic or have problems with your heart, kidney or liver.
  • Your doctor may check the level of prostate specific antigen (PSA) in your blood. This is done to monitor how well Firmagon is working for you. A decrease in PSA levels is usually a sign that your treatment is working.
Brief Description
Indication
Hormone-dependent Advanced Prostate Carcinoma (Stage D)
Administration
Initiation pack contains 2 vials each with 120 mg per vial & 6 mL sterile water for injection diluent Withdraw 3 mL of sterile water for injection diluent (supplied) & add to 1 of the 2 vials, swirl to mix - keep vial vertical at all times, do not shake Inject SC in abdomen within 1 hour of reconstitution Repeat for 2nd injection and use different injection site Maintenance pack contains 1 vial of 80 mg per vial & 4.2 mL sterile water for injection diluent Use 4.2 mL to reconstitute, withdraw 4 mL for dose of 80 mg
Adult Dose
Subcutaneous Advanced prostate cancer Adult: Loading dose: As 40 mg/mL solution: 240 mg (given as 2 separate injections of 120 mg). Maintenance: As 20 mg/mL solution: 80 mg once every 28 days, starting 28 days after the initial dose. Doses are administered in the abdominal area. Hepatic Impairment Mild-to-moderate: Dose adjustment not necessary Severe: Safety and efficacy not established; use caution
Renal Dose
Renal Impairment >50 mL/min: Dose adjustment not necessary <50 mL/min: Use caution
Contraindication
Hypersensitivity. Pregnancy and lactation.
Mode of Action
Degarelix, a synthetic decapeptide, reversibly and competitively binds to gonadotropin-releasing hormone (GnRH) receptors in the anterior pituitary gland, thereby decreasing secretion of luteinising hormone (LH) and follicle stimulating hormone (FSH), and subsequently reducing testicular androgen synthesis.
Precaution
Patient with congenital long QT syndrome, history of or risk factors for QT prolongation (e.g. cardiac failure, electrolyte imbalance) and CV disease; diabetes, risk factors for low BMD. Moderate to severe renal (CrCl <50 mL/min) and severe hepatic impairment. Lactation: excretion in milk unknown/not recommended
Side Effect
>10% Hot flashes (26%) Injection site erythema (17%) Injection site pain (28%) Weight gain (11%) Elevated liver enzymes (10%) 1-10% (selected) Arthralgia Back pain Fatigue HTN Injection site induration/swelling
Pregnancy Category Note
Pregnancy Category: X Lactation: excretion in milk unknown/not recommended
Interaction
Increased risk of QT prolongation with class IA (e.g. disopyramide) or class III (e.g. amiodarone) antiarrhythmics, antipsychotics, methadone and moxifloxacin.

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