Indications of Dexonex-C Drops

Eye: This combination is demonstrated in intense purulent conjunctivitis, new irritation of the shallow and more profound corneal layers and corneal ulceration. It is additionally utilized in keratitis disciformis and the more deep-seated shapes of post-herpetic keratitis, unfavorably susceptible conjunctivitis, unfavorably susceptible blepharitis, intense and inveterate iritis, persistent front uveitis and corneal damage from chemical radiation or warm burns, or infiltration of remote bodies. The combination is utilized in steroid-responsive provocative visual conditions for which a corticosteroid is shown and where bacterial disease or arisk of bacterial visual disease exists. The combination can too be utilized for post-operative aggravation and any other visual aggravation related with infection.

Ear: This combination is demonstrated in otitis externa, otitis media and persistent suppurative otitis media.

Pharmacology of Dexonex-C Drops

Dexamethasone may be a glucocorticoid. It has an anti-inflammatory and anti-allergic activity. It is utilized topically within the treatment of fiery conditions of the front section of the eye. Dexamethasone is ingested quickly after verbal organization with a half-life of around 190 minutes. Adequate assimilation may happen after topical application to the skin and eye to create systemic effects. Chloramphenicol may be a wide range bacteriostatic anti-microbial dynamic against a wide assortment of gram-negative and gram-positive living beings. Chloramphenicol applies its antibacterial impact by official to bacterial ribosomes and hindering bacterial protein union at an early organize

Dexonex-C Drops Administration & Dosage

Eye:
 

Bacterial Conjunctivitis: The recommended dosage regimen for the treatment of bacterial conjunctivitis is 1 to 2 drops instilled into the conjunctival sac (s) every 2 hours for 2 days and 1 or 2 drops every 4 hours for the next 5(five days) while awake.

Corneal Ulcers: The recommended dosage regimen for the treatment of comeal ulcer is 2 drops in the affected eye (s) every 15 minutes for the first 6 hours then 2 drops into the affected eye(s) every 30 minutes for the remainder of first day. On the second day, instill 2 drops in the affected eye (s) hourly. On the 3 to 14 days, place 2 drops in the affected eye (s) every 4 hours. Treatment may be continued after 14 days if corneal re-epithelialization has not occurred.

Ear: For all infections, 2 to 3 drops every 2 to 3 hours initially. Frequency should be decreased gradually as warranted by improvement in clinical signs. Care should be taken not to discontinue therapy prematurely.

Interaction

On the off chance that Chloramphenicol is ingested from eye when taking anticoagulants e.g. warfarin, there may be an increment within the impact of this medication. Activity of Chloramphenicol will be hindered on the off chance that given at the same time with Phenobarbital. The restorative viability of Dexamethasone may be diminished with the concomitant organization of phenytoin, phenobarbitone, ephedrine and rifampicin.

Contraindications

The combination is contraindicated in epithelial herpes simplex cornealis, parasitic, viral, tuberculous and other contaminations of the eye and in glaucoma. Myelosuppression amid past introduction to Chloramphenicol. Extreme touchiness to Chloramphenicol & Dexamethasone Phosphate or to any other fixings of the arrangements.

Dexonex-C Drops Side Effect

Unfavorable responses seen with Chloramphenicol are transitory visual burning or inconvenience and other detailed responses incorporate stinging, redness, tingling, conjunctivitis, remote body sensation, photophobia, obscured vision, dryness and eye torment. Unfavorably susceptible sensitization may happen with the nearby utilize of Chloramphenicol. Rise of intraocular weight with conceivable improvement of glaucoma, occasional optic nerve harm and back subcapsular cataract arrangement.

Pregnancy & Lactation

There are no satisfactory and well-controlled ponders in pregnant ladies. This medicate ought to be utilized amid pregnancy as it were on the off chance that the potential advantage legitimizes the potential hazard to the baby. Caution ought to be worked out when Chloramphenicol and Dexamethasone ophthalmic arrangement is managed to a nursing mother.

Precautions & Warnings

The plausibility of tireless contagious diseases of the cornea ought to be considered after delayed corticosteroid dosing. Drawn out utilize of steroids containing items may result in back subcapsular cataract arrangement and glaucoma with optic nerve harm. Intraocular weight checking is required. Delayed utilize of anti-microbials may result within the excess of non-susceptible life forms, counting organisms. In the event that modern diseases show up amid treatment, the sedate ought to be suspended and elective treatment ought to be foundations.

Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.