Premarin Cream is a female sex hormone (estrogen). It is a part of female hormonal replacement therapy which helps in treating estrogen deficiency symptoms like hot flushes (red and warm face) and vaginal dryness. Premarin Cream is also used to prevent osteoporosis (thinning and weakening of bone) in postmenopausal women, who are at high risk of fractures and can not take other preventive medicines for osteoporosis. It can be taken with or without food, but remember to take it at a fixed time each day for better efficacy. The dose and duration will be decided by your doctor so that you get the right amount to control your symptoms. The treatment should not be stopped abruptly without consulting your doctor as this may affect the potency of this medicine. The most common side effects of this HRT are headaches, breast pain, irregular vaginal bleeding or spotting, abdominal cramps or bloating, nausea, vomiting, and hair loss. If any of these side effects or any other symptoms which you think are because of this medicine persist for a longer duration, please inform your doctor. Before taking this medicine, it is important to tell your doctor if you are taking or have recently taken any other medicines for the same disease or other diseases. Before you initiate with this HRT, you must consult the doctor if you have a history of unexplained vaginal bleeding or if you have ever had a blood clot in your legs or your lungs. If you are pregnant or breastfeeding, you should tell your doctor before taking this medicine. Your doctor may suggest you some diagnostic or laboratory tests to know the effects and side effects of this medicine on your body.