Giane 35, a combination of two hormone drugs, is used to treat polycystic ovarian syndrome (PCOS) symptoms include excessive hair growth (hirsutism), acne, and irregular menstrual cycles. Avoid using any other contraceptive pills since it also functions as a contraceptive.

Pharmacology

Cyproterone is a steroid that has antiandrogenic, progestogenic, and antigonadotrophic properties. Its antiandrogenic action is achieved by inhibiting androgen receptors. It also has a negative feedback impact on the hypothalamic-pituitary-ovarian circuits, which decreases androgen production. The estrogen component (Ethinylestradiol) raises levels of sex hormone-binding globulin (SHBG) and consequently lowers androgen levels in the blood. SHBG levels are not reduced by cyproterone.

Cyproterone, when administered alone in women, causes menstrual cycle disruptions, which are prevented when coupled with Ethinylestradiol. When taken in a cyclic pattern, this pill offers the extra benefit of preventing ovulation and possible pregnancy.

After oral administration, the components of this tablet are promptly absorbed. After 6 to 12 days of daily dosage, a 4-fold rise in plasma levels occurs due to Cyproterone's lengthy terminal half-life. Long-term treatment with this substance (36 months) had no discernible effect on lipid metabolism. There was a tendency toward higher plasma cholesterol and triglyceride levels. Low-density lipoprotein (LDL) levels fell slightly, but high-density lipoprotein (HDL) levels rose (HDL).