Indications of Benozol Ophthalmic Solution

Brin Doze Mid-Eye Drop Suspension is presented as a monotherapy or as an adjunct to beta-blockers in the treatment of elevated intraocular pressure or increased intraocular pressure in open-angle glaucoma.

Pharmacology of Benozol Ophthalmic Solution

Carbonic anhydrase (CA) is an enzyme found in many tissues of the body, including the eyes. It catalyzes a reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid. It exists in the form of several isoenzymes, the most active being carbonic anhydrase II (CAII), present mainly in red blood cells, but also in other tissues. Inhibition of carbonic anhydrase in the processes of the ciliary body of the eye reduces the secretion of aqueous humor, presumably by slowing the formation of bicarbonate ions with a subsequent reduction in sodium and fluid transport.

 After topical ocular administration, brinzolamide inhibits aqueous humor formation and reduces elevated intraocular pressure. Elevated intraocular pressure is a major risk factor in the pathogenesis of optic nerve damage and glaucoma visual field loss.

Dosage & Administration of Benozol Ophthalmic Solution

The recommended dose is one drops of this eye drop in the conjunctival sac of the affected eye(s) twice daily. Some patients may have a better response with one drop three times a day. Shake well before use.