Miragon 25 - 1 strip

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Ashik Medical

Bolaspur Mymensingh

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Description

Medicine Overview of Miragon 25mg Tablet

Introduction

Miragon 25 is used to treat symptoms of overactive bladder that includes increased or frequent urination, urgent need to urinate and inability to control urination. It helps to relax the muscle surrounding the bladder and increase it's ability to store urine. Miragon 25 is advised to take it in a dose and duration as per prescription. It can be taken with or without food. Swallow the medicine as a whole without crushing or chewing it. You should not stop taking the medicine without consulting the doctor as it may lead to the worsening of your symptoms. The course of the treatment should be completed for better efficacy of the medicine. Some common side effects of this medicine are hypertension, common cold symptoms (nasopharyngitis), urinary tract infection, and headache. If any of the side effects bother you or persist, consult the doctor without delay. Before receiving the treatment, inform your doctor if you are on any medication for any other health condition. If you are pregnant or breastfeeding, tell your doctor prior to the treatment. Patients with liver or kidney disease must be cautious while receiving the prescription and they must receive regular follow-ups as per the doctor's advice.

Uses of Miragon 25

Overactive bladder (OAB) symptoms

Side effects of Miragon 25

Common

Constipation
Headache
High blood pressure
Nasal inflammation
Urinary tract infection

How to use Miragon 25

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Miragon 25 may be taken with or without food, but it is better to take it at a fixed time.

How Miragon 25 works

Miragon 25 is a beta 3-receptor agonist. It works by activating the receptor in the bladder, causing the bladder muscles to relax. It prevents frequent, urgent or uncontrolled urination.

Quick Tips

Mirago 50 Tablet ER helps you to have better control over your urination. It relaxes your bladder which increases its capacity to hold urine thereby reducing the need to pass urine.

It causes less drowsiness and constipation than other medicines for overactive bladder.

It may raise your blood pressure. Monitor your blood pressure regularly.

Do not stop taking this medicine if you do not notice an improvement in your symptoms as it may take some time for your bladder to adapt and your symptoms to improve.

Brief Description

Indication

Overactive bladder, with symptoms of urge urinary incontinence, urgency, and urinary frequency

Administration

May be taken with or without food: Swallow whole, do not chew/divide/crush.

Adult Dose

Overactive Bladder Indicated for overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency 25 mg PO qDay 25 mg dose is typically effective within 8 weeks May increase to 50 mg PO qDay based on individual efficacy and tolerability Hepatic impairment Moderate (Child-Pugh B): Not to exceed 25 mg/day Severe (Child Pugh C): Not recommended

Renal Dose

Renal impairment Severe (CrCl 15-29 mL/min): Not to exceed 25 mg/day ESRD: Not recommended

Contraindication

Hypersensitivity. Severe uncontrolled HTN.

Mode of Action

Beta-3 adrenergic receptor agonist which causes relaxation of the detrusor smooth muscle of the urinary bladder and increases bladder capacity.

Precaution

End-stage renal disease, severe renal impairment; moderate (Child-Pugh Class B) & severe hepatic impairment (Child-Pugh Class C); severe uncontrolled HTN. Known history of QT prolongation or taking medicines known to prolong QT interval; bladder outlet obstruction & taking antimuscarinic medications for OAB. Women of childbearing potential not using contraception. Pregnancy & lactation. Childn <18 yr. Lactation: Unknown whether distributed in breast milk; excretion in breast milk possible; discontinue nursing or the drug taking into account the importance of the drug to the mother

Side Effect

>10% Elevated BP occurring predominantly in patients with preexisting hypertension (7-11%) 1-10% Dry mouth (3-9%),Nasopharyngitis (3-4%),UTI (3-6%),Headache (2-4%),Influenza (2-3%),Constipation (2-3%),Dizziness (2%),Arthralgia (2%),Cystitis (2%),Back pain (1-3%),Sinusitis (1-3%),URTI (1-2%),Arthralgia (1-2%),Diarrhea (1-2%),Tachycardia (1-2%),Fatigue (1%),Abdominal pain (0-1%),Reports of neoplasms (0-1%) <1% Cardiac disorders (eg, palpitations, elevated BP),Eye Disorders (eg, glaucoma, blurry vision),GI disorders (eg, dyspepsia, gastritis, abdominal distension),Rhinitis,Elevations in GGT, AST, ALT, LDH, Renal and urinary disorders (eg, nephrolithiasis, bladder pain), Reproductive system disorders (eg, vulvovaginal pruritis, vaginal infection) Skin and subcutaneous tissue disorders (eg, urticaria, leukocytoclastic vasculitis, rash, pruritus, purpura, lip edema) Stevens-Johnson syndrome associated with increased serum ALT, AST and bilirubin

Interaction

Increased AUC of strong CYP3A/P-gp inhibitors eg, ketoconazole, itraconazole, ritonavir, clarithromycin. Decreased plasma conc by CYP3A/P-gp inducers. Increased Cmax & AUC of metoprolol, despiramine & digoxin. Thioridazine, type 1C antiarrhythmics (eg flecainide, propafenone), TCAs. Potential P-gp inhibition of dabigatran.

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