Introduction
Methomol is a muscle relaxer. It provides relief from the discomfort associated with acute, painful musculoskeletal conditions such as rigidity, tension, stiffness, and muscle spasms. Methomol is generally administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. It may be only part of a treatment program that includes other medicines and therapies. The most common side effects of this medicine include injection site reactions (such as pain, redness, and swelling), headache, drowsiness, fatigue, vomiting, constipation, dry mouth, and sweating. If any of these side effects persist or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms. Before using it, you should let your doctor know if you have problems with your heart, liver, or kidneys. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine. If you are pregnant or breastfeeding, it is important to ask the advice of your doctor before taking this medicine. Your doctor may also regularly monitor your kidney function, liver function, and levels of blood components if you are taking this medicine for long-term treatment.
Side effects of Methomol
Common
- Sleepiness
- Dryness in mouth
How to use Methomol
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Methomol works
Methomol is a muscle relaxant. It works on the centres in the brain and spinal cord to relieve muscle stiffness or spasm without reduction in strength. This improves pain and movement of muscles.
What if you forget to take Methomol?
If you miss a dose of Methomol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Indication
Muscle Spasm, Tetanus
Administration
IV Administration Direct IV: Administer undiluted at not to exceed 3 mL (=300 mg undiluted)/min Infusion: Dilute 1 g with up to 250 mL D5W or NS; avoid extravasation, since injection is hypertonic Administer IV while in recumbent position Maintain position 15-30 min following infusion IM Administration Not to exceed 500 mg (5 mL undiluted) should be given into each gluteal region
Adult Dose
Oral Muscle spasm Adult: Initially: 1.5 g q6hr for 48-72 hours; not to exceed 8 g/day THEN decrease to 4-4.5 g/day divided q4-8hr Parenteral 1 g IV/IM; additional doses at q8hr until PO; not to exceed 3 g/day Total parenteral dose should not exceed 3 g/day for >3 days, unless treating tetanus; if condition persists, may repeat therapy after drug-free interval of 48 hr Intravenous Tetanus Adult: Adjunct therapy: Initial 1-2 g IV injection (at 300 mg/min), THEN Additional 1-2 g IV infusion for total dose of 3 g initially May repeat 1-2 g IV q6hr until can give NG or PO Total oral dosage of up to 24 g daily may be needed. Elderly: Dose may need to be reduced by half.
Child Dose
Tetanus 15 mg/kg/dose IV q6hr PRN or 500 mg/m²/dose; not to exceed 1.8 g/m²/day for 3 days only Muscle Spasm <16 years: Safety and efficacy not established >16 years: 1500 mg PO q6hr for 48-72 hours; not to exceed 8 g/day THEN decrease to 4-4.5 g/day divided q4-8hr
Renal Dose
Renal failure: Not studied; parenteral dosage form contraindicated due to presence of polyethylene glycol
Contraindication
Hypersensitivity, Do not admin parenteral solutions in patients with renal impairment, epilepsy or history of epilepsy. Coma or pre-coma states, brain damage, myasthenia gravis
Mode of Action
Unknown; Methocarbamol is a centrally acting skeletal muscle relaxant whose precise mode of action is not known. It is said to cause general depression of the central nervous system.
Precaution
May cause drowsiness/dizziness; patients should not ingest alcohol or other CNS depressants May take with food to avoid stomach upset Half-life increases with hepatic impairment IV formulation not for use in renal impairment (contains polyethylene glycol; injection rate should not exceed 3 mL/min May interfere with screening tests for 5-HIAA and vanillylmandelic acid (VMA) Use injection with caution in patients with a history of seizures Sedative effects potentiated when used with other sedatives Medication is poorly tolerated in the elderly Pediatric IV dosing approved only for tetanus Lactation: Not known if excreted in breast milk; use caution
Side Effect
Nausea, anorexia, fever, headache, blurred vision, lassitude, drowsiness, dizziness, restlesness, anxiety, confusion, convulsions; hypersensitivity reactions e.g. rashes, pruritus, urticaria, angiodema. Parenteral: Flushing and a metallic taste; incoordination, diplopia, nystagmus, vertigo; sloughing and thrombophloebitis at the site of inj. Potentially Fatal: Parenteral: Syncope, hypotension, bradycardia, anaphylaxis.
Interaction
Action potentiated by alcohol and other CNS depressants. May inhibit effect of pyridostigmine, use with caution with anticholinesterase agents.