Metherspan Injection - (200mcg/Ml)

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Ashik Medical

Bolaspur Mymensingh

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Description

Medicine Overview of Metherspan 200mcg/ml Injection

Indication

Postpartum and post-abortion bleeding, 3rd stage of labour, Uterine bleeding, Postpartum haemorrhage

Adult Dose

Pospartum or Postabortion Hemorrhage Oral: 0.2-0.4 mg PO q6-12hr PRN for 48 hr or until danger of uterine atony has passed; no more than 1 week Parental 0.2 mg IM; may repeat in 2-4hr; not to exceed 5 doses total Give IV only in emergency because of potential for HTN & CVA Give over >1 minute & monitor BP

Contraindication

Pregnancy, 1st and 2nd stage of labour, patients with preeclampsia, eclampsia or threatened spontaneous abortion; porphyria.

Mode of Action

Ergometrine causes contraction of the uterine muscle. At low doses, there is an increase in frequency and amplitude of contractions while at higher doses, the basal tone of the uterus is increased. Ergometrine also causes vasoconstriction of peripheral and cerebral vessels.

Precaution

Breech and abnormal foetal presentation; hypertension; chronic anaemia; hepatic, renal, respiratory or cardiac impairment; toxemia; lactation; hypocalcaemia. Monitor BP, pulse and uterine response. Lactation: excreted in milk; adverse effect on the nursing infant; may inhibit lactation; use not recommended

Side Effect

Nausea, vomiting, abdominal pain, diarrhoea; headache, dizziness; tinnitus; chest pain, palpitation, bradycardia, transient hypertension and other cardiac arrhythmias; dyspnoea, sometimes rashes, shock. Potentially Fatal: MI, pulmonary oedema.

Interaction

Halothane causes relaxation of uterine muscle and may interfere with ergometrine action. Enhanced uterotonic effect with prostaglandins and oxytocin. Concurrent admin with CYP3A4 inhibitors may lead to vasospasm, cerebral ischaemia and/or ischaemia of extremities. Potentially Fatal: Enhanced vasoconstrictive effects with sympathomimetics and other vasoconstrictors.

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